Bilateral Right Cerebrum.Limbic Lobe.Parahippocampal Gyrus.Gray Matter.Brodmann area 34 corresponds to the gray matter of Brodmann area 34 located in the parahippocampal gyrus of the limbic lobe on the right side, represented bilaterally in the Talairach 2 mm atlas. Brodmann area 34 is generally associated with the entorhinal cortex, a key interface between the neocortex and the hippocampal formation, involved in memory consolidation, spatial navigation, and processing of multimodal sensory information relevant to episodic memory. This region receives and integrates inputs from widespread cortical association areas and projects to hippocampal structures, contributing to the encoding and retrieval of declarative memories and contextual information. There is no direct Wikipedia article for “Brodmann area 34,” but it is closely related to the entorhinal cortex: Entorhinal cortex.
The bilateral right parahippocampal gyrus gray matter in Brodmann area 34, a medial temporal-limbic region involved in olfactory processing and memory, appears in genetic literature primarily through broader parahippocampal and medial temporal lobe measures rather than BA34-specific analyses. Large-scale GWAS of brain structure (e.g., ENIGMA and UK Biobank) have identified common variants near genes such as WNT3, DPP4, KANSL1, and others that influence parahippocampal cortical thickness and volume, which are often bilaterally assessed and can include BA34 in atlas-based parcellations like Talairach 2mm. This region has been implicated in genetic risk for Alzheimer’s disease and other dementias via APOE, BIN1, CLU, and CR1, which are associated with medial temporal atrophy and parahippocampal volume loss, as well as in schizophrenia and major depressive disorder through polygenic risk scores that correlate with altered parahippocampal and limbic gray matter. Parahippocampal and adjacent entorhinal cortex measures influenced by genetic variants have also been linked to episodic memory performance, spatial navigation, and olfactory identification traits, all functions associated with BA34. However, most GWAS and imaging-genetics studies treat the parahippocampal gyrus as a composite region, so current evidence connects genetic variants and psychiatric/neurodegenerative disorders to structural and functional alterations in this broader parahippocampal territory rather than isolating effects uniquely to right BA34 gray matter in the Talairach 2mm Atlas.
Overview generated by GPT-4o (2026).
Region ID: 178
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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