Bilateral Right Cerebrum.Limbic Lobe.Parahippocampal Gyrus.Gray Matter.Brodmann area 35 corresponds to the right-side gray matter of Brodmann area 35 within the parahippocampal gyrus of the limbic lobe, part of the medial temporal cortex. This region, often associated with the perirhinal cortex, plays key roles in declarative memory, particularly recognition memory, familiarity judgments, and the integration of multimodal sensory information related to objects. It contributes to medial temporal lobe memory circuits involving the hippocampus and entorhinal cortex, and is implicated in processes such as associative learning and mnemonic binding. Cytoarchitectonically, BA35 is a transitional cortex between neocortex and allocortex, and is frequently affected in neurodegenerative conditions such as Alzheimer’s disease. There is no direct link; a closely related structure is the Perirhinal cortex.
The parahippocampal gyrus (BA35), part of the limbic system and medial temporal lobe, has been implicated in multiple genetic and GWAS findings, particularly through studies of medial temporal or entorhinal/parahippocampal cortical thickness and volume rather than strictly BA35-specific analyses. Large neuroimaging GWAS (e.g., ENIGMA and UK Biobank) have identified associations between genetic variants in loci such as APOE (notably ε4), BIN1, CLU, CR1, and other Alzheimer’s disease risk genes with reduced medial temporal and parahippocampal cortical thickness, accelerated atrophy, and amyloid/tau pathology, consistent with BA35’s known vulnerability in early Alzheimer’s and primary age-related tauopathy. Variants in genes related to neurodevelopment and synaptic function (e.g., BDNF, COMT, and several glutamatergic and GABAergic pathway genes) have been associated with parahippocampal and entorhinal morphology, memory performance, and episodic recall in imaging genetics studies, linking BA35-adjacent structure and function to cognitive traits. GWAS of schizophrenia, major depressive disorder, and bipolar disorder implicate common risk loci that show downstream effects on medial temporal/limbic gray matter, including the parahippocampal region, although these are typically indirect through global or network-level imaging endophenotypes. Additionally, genetic variants affecting tau (MAPT haplotypes) and TDP-43–related pathways have been associated with selective medial temporal and parahippocampal involvement in frontotemporal lobar degeneration and limbic-predominant age-related TDP-43 encephalopathy (LATE). Overall, BA35 sits within a genetically sensitive medial temporal hub where polygenic influences on neurodegeneration, memory, and affective disorders converge, even though most GWAS do not isolate this Talairach 2 mm label region specifically.
Overview generated by GPT-4o (2026).
Region ID: 141
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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