Bilateral Right Cerebrum Limbic Lobe Posterior Cingulate Gray Matter Brodmann area 30 corresponds to the retrosplenial cortex, a small, cytoarchitectonically defined region located in the posterior cingulate gyrus adjacent to the splenium of the corpus callosum. Brodmann area 30 is part of the limbic network and is strongly interconnected with the hippocampal formation, parahippocampal cortex, and medial parietal regions, supporting functions in episodic memory, spatial navigation, and contextual association. It contributes to integrating visuospatial and mnemonic information and is often engaged during autobiographical memory recall and internally directed cognition. There is no direct link for Brodmann area 30; a closely related structure is the Posterior cingulate cortex.
Genetic associations specifically targeting the bilateral Right Cerebrum.Limbic Lobe.Posterior Cingulate.Gray Matter.Brodmann area 30 (BA30) from the Talairach 2 mm atlas are sparse, as most imaging genetics and GWAS work examines broader posterior cingulate cortex (PCC), retrosplenial cortex, or limbic networks rather than this cytoarchitectonic field alone. Large-scale brain MRI GWAS (e.g., ENIGMA, UK Biobank) have identified multiple loci (including variants near genes such as MAPT, APOE, CRHR1, SORL1, and others) associated with PCC and adjacent medial parietal cortical thickness, surface area, or volume, often in the context of Alzheimer’s disease risk, default mode network connectivity, and neurodegeneration. APOE ε4 and loci in the MAPT region on 17q21 are repeatedly associated with structural and functional alterations of PCC/retrosplenial regions, particularly hypometabolism and atrophy in Alzheimer’s disease and mild cognitive impairment; PCC volume and connectivity have also been linked genetically to schizophrenia, major depression, and autism via polygenic risk scores and GWAS of resting-state networks, though these analyses rarely isolate BA30. GWAS of cognitive traits (episodic memory, spatial navigation, and general intelligence) have reported associations between variants in synaptic and neurodevelopmental genes and structural/functional measures in PCC–retrosplenial areas, implicating glutamatergic signaling, synaptic plasticity, and axonal guidance pathways. Overall, genetic findings point to BA30 as part of a broader posterior cingulate/retrosplenial hub whose morphology and connectivity are modulated by common variants related to neurodegeneration, psychiatric disease risk, and cognitive function, but direct BA30-specific GWAS results remain limited, with most evidence inferred from studies of the PCC and medial parietal limbic circuitry.
Overview generated by GPT-4o (2026).
Region ID: 665
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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