The bilateral Right Cerebrum.Limbic Lobe.Uncus.White Matter refers to the subcortical myelinated fiber tracts underlying the uncus, a medial temporal lobe structure that forms part of the parahippocampal gyrus and is closely associated with the limbic system. The uncus overlies critical components of the olfactory cortex and is adjacent to the amygdala and hippocampal formation, playing roles in olfaction, emotional processing, and memory. Its white matter contains association and projection fibers that interconnect limbic structures with other cortical and subcortical regions, facilitating integration of emotional, mnemonic, and sensory information. There is no direct link for this specific white matter subdivision; a related structure is the Uncus.
Genetic associations specifically targeting the bilateral Right Cerebrum Limbic Lobe Uncus white matter as defined in the Talairach 2 mm Atlas are sparse, but converging evidence from GWAS and imaging‑genetics studies implicates genes and variants that influence limbic and medial temporal white matter microstructure, including regions encompassing the uncus. Large neuroimaging GWAS (e.g., ENIGMA, UK Biobank) have identified common variants in genes involved in axonal guidance, myelination, and synaptic plasticity—such as CACNA1C, BDNF, NRG1, CNTNAP2, and various oligodendrocyte‑related loci—that correlate with fractional anisotropy and other diffusion MRI metrics in limbic white matter tracts, including fronto‑limbic and temporo‑limbic pathways that course near the uncus. These genetic influences on limbic white matter integrity have been linked to risk and intermediate phenotypes for major depressive disorder, bipolar disorder, schizophrenia, anxiety disorders, and post‑traumatic stress disorder, as well as traits like neuroticism, emotional regulation capacity, and memory performance. Additionally, APOE and other Alzheimer’s disease‑related variants show associations with early white matter changes in medial temporal regions, and epilepsy GWAS highlight genes affecting hippocampal and parahippocampal circuitry that extend into uncinate and adjacent limbic white matter. Overall, while few studies isolate the uncus white matter label per se, genetic effects on limbic and uncinate fasciculus connectivity, myelin integrity, and vulnerability to neuropsychiatric and neurodegenerative disorders are highly relevant to this atlas‑defined region.
Overview generated by GPT-4o (2026).
Region ID: 27
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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