The bilateral Right Cerebrum.Occipital Lobe.Cuneus refers to the cuneus portion of the occipital lobe in the right cerebral hemisphere, involved primarily in early visual processing. This wedge-shaped cortical region lies between the parieto-occipital sulcus and the calcarine sulcus on the medial surface of the occipital lobe and contributes to the analysis of basic visual features such as orientation, motion, and spatial organization, particularly within central visual fields. Functionally, the cuneus participates in integrating visual input for higher-order processes including visual attention, visuospatial perception, and aspects of visual memory. It maintains reciprocal connections with primary and associative visual areas (e.g., V1, V2) and receives input from thalamic nuclei, notably the lateral geniculate nucleus, forming part of the dorsal visual processing stream. There is no direct link for “Right Cerebrum.Occipital Lobe.Cuneus”; a related structure is the cuneus cortex: Cuneus
The bilateral Right Cerebrum Occipital Lobe Cuneus, as defined in the Talairach 2mm atlas, has been repeatedly implicated in genetic studies of visual, cognitive, and psychiatric traits, although most findings reference the cuneus more generally rather than this specific Talairach subdivision. GWAS and imaging-genetics studies show that cortical thickness and surface area of occipital regions including the cuneus are heritable and associated with common variants near genes involved in neurodevelopment and synaptic function, such as those in Wnt signaling and axon guidance pathways. Variants in APOE, CLU, and other Alzheimer’s disease–related loci have been associated with altered cuneus structure and functional activation, particularly in tasks involving visual processing and memory, and the cuneus has been highlighted in polygenic risk studies of Alzheimer’s disease and age-related cortical atrophy. Large-scale brain-wide association studies in schizophrenia, major depressive disorder, and bipolar disorder report cuneus volume or activation differences linked to polygenic risk scores, with several risk loci (e.g., in CACNA1C, ZNF804A, and GRM3) showing downstream effects on occipital and midline cortical networks that include the cuneus. In addition, GWAS of traits such as intelligence, educational attainment, and reading ability have found genetic correlations with occipital/cuneus morphology and connectivity, suggesting that variants influencing early visual and visuospatial processing may contribute to higher-order cognitive phenotypes. Overall, the cuneus emerges as a genetically influenced node in visual and default-mode–related networks, with its structure and function modulated by polygenic variation implicated in neurodevelopmental, neurodegenerative, and psychiatric disorders, though precise, region-specific genetic associations for the bilateral right cuneus in the Talairach 2mm atlas remain relatively coarse and typically embedded in broader occipital or midline cortical analyses.
Overview generated by GPT-4o (2026).
Region ID: 476
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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