The bilateral Right Cerebrum.Parietal Lobe.Postcentral Gyrus.Gray Matter.Brodmann area 40 corresponds primarily to the supramarginal gyrus region of the inferior parietal lobule, a heteromodal association cortex involved in integrating somatosensory, auditory, and visual information. Functionally, this area contributes to language processing (particularly phonological and semantic integration), spatial attention, tactile perception, and aspects of praxis and body schema. Its gray matter circuitry is heavily interconnected with temporal and frontal language areas, somatosensory cortices, and multimodal association networks that support higher-order cognition, including working memory and social perception. There is no direct link for the full Talairach label; a closely related structure is the supramarginal gyrus: Supramarginal gyrus.
Genetic associations involving the bilateral right postcentral gyrus gray matter in Brodmann area 40 (as defined in the Talairach 2 mm atlas) are typically inferred from imaging‑genetics and GWAS studies that treat this region as part of the inferior parietal/postcentral somatosensory network rather than as a uniquely isolated locus. Variants in genes influencing cortical thickness, surface area, and gyrification—such as those in the microtubule‑associated and synaptic pathways (e.g., MIR137, CACNA1C, GRIN2B, CNTNAP2, DISC1, and several loci identified by large ENIGMA and UK Biobank GWAS of regional cortical morphology)—have been associated with structural variation in the parietal and postcentral gyri, including right‑hemisphere regions overlapping BA40. This territory has repeatedly been implicated in genome‑wide studies of neurodevelopmental and psychiatric disorders, including schizophrenia, autism spectrum disorder, attention‑deficit/hyperactivity disorder, dyslexia, and developmental coordination disorder, where risk alleles often show downstream effects on parietal somatosensory and language‑related circuits. GWAS of cognitive traits (working memory, mathematical ability, reading and phonological processing, general intelligence) and sensorimotor phenotypes have linked risk loci to altered activation or morphology in inferior parietal/postcentral areas, with BA40 frequently involved in multimodal integration and higher‑order somatosensory processing. Although no single “BA40‑specific” risk gene is established, convergent evidence from polygenic risk scores, large‑scale brain‑structure GWAS, and disorder‑focused imaging‑genetics studies indicates that common variants affecting synaptic plasticity, cortical development, and axonal guidance contribute to interindividual differences in the structure and function of this right parietal postcentral region and its involvement in neuropsychiatric and cognitive phenotypes.
Overview generated by GPT-4o (2026).
Region ID: 778
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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