The bilateral Right Cerebrum.Parietal Lobe.Postcentral Gyrus.Gray Matter.Brodmann area 5 corresponds to a higher-order somatosensory association region located dorsally in the parietal lobe, just posterior to the primary somatosensory cortex (Brodmann areas 1–3). This area integrates multimodal sensory inputs—particularly proprioceptive, tactile, and kinesthetic information—to contribute to spatial orientation, body schema, and coordination of complex motor behaviors based on sensory feedback. Neuronal populations in Brodmann area 5 participate in transforming somatic sensory signals into more abstract representations of limb position and movement, facilitating sensorimotor integration necessary for goal-directed actions and interaction with the environment. There is no direct link for “Brodmann area 5”; see the related structure Parietal lobe.
The bilateral right postcentral gyrus gray matter in Brodmann area 5 (superior parietal/posterior somatosensory association cortex) has been implicated in several genetic associations through neuroimaging GWAS and disorder-focused studies, although most work targets the broader superior parietal lobule or postcentral gyrus rather than BA5 specifically. Large-scale brain MRI GWAS (e.g., ENIGMA, UK Biobank) have identified common variants near genes involved in neuronal development and synaptic function (such as MAPT, CENP, and multiple glutamatergic pathway genes) that influence cortical thickness and surface area in parietal regions encompassing BA5. Functionally, BA5 is central to sensorimotor integration, body representation, and visuospatial processing, and genetic studies of these traits show overlap with loci affecting parietal morphology. In neurodevelopmental disorders, polygenic risk for autism spectrum disorder and schizophrenia has been associated with altered parietal/postcentral structure and connectivity, with risk variants in synaptic and neurodevelopmental genes (e.g., CACNA1C, GRIN2A, CNTNAP2) contributing to parietal abnormalities. Similarly, GWAS of attention-deficit/hyperactivity disorder, dyslexia, and general cognitive ability have reported associations between risk loci and structural or functional differences in superior parietal and postcentral regions, highlighting BA5’s role in attentional control and higher-order sensory processing. Pain perception and somatosensory traits, studied via imaging genetics, also implicate parietal somatosensory cortices, with variants in ion channel and neurotransmission genes modulating postcentral activation, though these findings remain regionally coarse. Overall, current genetic evidence links BA5-containing parietal cortex to polygenic influences on cognition, sensorimotor integration, neurodevelopmental and psychotic disorders, and pain-related processing, but direct, BA5-specific genetic associations from the Talairach 2 mm atlas remain limited, with most insights derived from broader parietal lobe and postcentral gyrus analyses.
Overview generated by GPT-4o (2026).
Region ID: 1096
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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