The bilateral Right Cerebrum.Parietal Lobe.Superior Parietal Lobule.Gray Matter.Brodmann area 7, as defined in the Talairach labels 2 mm Atlas, corresponds to a cytoarchitectonic region in the superior parietal lobule implicated in high-level visuospatial processing, spatial attention, and sensorimotor integration. BA7 receives convergent inputs from visual, somatosensory, and premotor areas, contributing to the construction of internal representations of space and the body’s position within it, and plays a key role in visually guided actions, coordinate transformations, and the integration of proprioceptive and visual information for movement planning. Functionally, this region is involved in tasks requiring mental rotation, spatial navigation, and the manipulation of spatial information in working memory, and is part of parietal networks supporting goal-directed behavior and complex motor coordination. There is no direct Wikipedia article for this exact bilateral Talairach label; a closely related structure is the Superior parietal lobule.
The bilateral superior parietal lobule (Brodmann area 7) has been repeatedly implicated in imaging genetics and GWAS of brain structure, cognition, and neuropsychiatric risk, although most findings are regionally broader than this precise Talairach label. Large-scale MRI GWAS from ENIGMA and UK Biobank have identified multiple loci (including variants in genes such as HMGA2, KIAA0586, WNT signaling components, and polygenic measures of brain size and cortical surface area) associated with parietal lobe cortical thickness, surface area, and gray matter volume, with BA7 contributing to these measures of parietal morphology. Polygenic scores for intelligence, educational attainment, and working memory correlate with structural and functional variation in superior parietal regions, supporting a role in visuospatial processing and attentional control. BA7 is commonly implicated in risk for schizophrenia, bipolar disorder, and major depression through case–control and polygenic risk score imaging studies, which show genetically influenced volume and connectivity differences in the posterior parietal cortex. Alzheimer’s disease and other dementias show genetically modulated atrophy and hypometabolism extending into BA7, particularly in carriers of APOE ε4 and other AD-risk alleles identified in GWAS, while autism spectrum disorder and ADHD studies report parietal alterations linked to common variants in synaptic and neurodevelopmental genes (e.g., CNTNAP2, DISC1-related pathways) that affect fronto-parietal networks. In summary, genetic influences on BA7 gray matter largely reflect broad neurodevelopmental and neurodegenerative pathways affecting parietal cortex morphology, cognitive function, and vulnerability to major psychiatric and neurocognitive disorders, rather than region-specific single-gene effects.
Overview generated by GPT-4o (2026).
Region ID: 1040
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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