The bilateral Right Cerebrum.Parietal Lobe.Supramarginal Gyrus.Gray Matter.Brodmann area 40 corresponds to a region in the inferior parietal lobule implicated in multimodal sensory integration, phonological processing, and aspects of spatial attention and body representation. Brodmann area 40, centered on the supramarginal gyrus, receives converging auditory, somatosensory, and visual inputs and is involved in language-related functions such as mapping sounds to articulatory and orthographic patterns, as well as in higher-order processes including empathy and theory of mind. It contributes to the dorsal language stream and participates in networks supporting working memory, praxis, and the perception of biological motion. There is no direct link for “Brodmann area 40,” but it is closely related to the Supramarginal gyrus.
The supramarginal gyrus (Brodmann area 40) has been implicated in multiple genetically influenced traits and disorders through imaging genetics and GWAS of brain structure and function, though associations are typically reported at the level of parietal cortex or specific supramarginal clusters rather than the Talairach 2 mm label itself. Variants in genes involved in synaptic plasticity, neurodevelopment, and axon guidance—such as BDNF, CNTNAP2, DISC1, and NRG1—have been linked to altered supramarginal or inferior parietal gray matter volume and connectivity in schizophrenia, autism spectrum disorder, and major depressive disorder. Polygenic risk scores for schizophrenia, bipolar disorder, and autism show correlations with structural and functional alterations in inferior parietal/supramarginal regions supporting language, social cognition, and multisensory integration. GWAS of cortical thickness and surface area have identified loci (e.g., near HMGA2, TBR1, and multiple neurodevelopmental genes) associated with parietal lobe metrics, including supramarginal-adjacent parcels, and these structural measures are in turn associated with cognitive performance, reading ability, and working memory. Structural and functional variation in BA40 has also been implicated in dyslexia and specific language impairment in genetic studies focusing on FOXP2-related and DCDC2/KIAA0319 pathways, as well as in attention-deficit/hyperactivity disorder via dopaminergic and glutamatergic genes that modulate fronto-parietal networks. Overall, genetic influences on the supramarginal gyrus appear to act through broad neurodevelopmental and synaptic mechanisms that shape parietal cortical morphology and connectivity, contributing to risk and phenotypic variation across language, social cognition, attention, and psychiatric disorders.
Overview generated by GPT-4o (2026).
Region ID: 928
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
This resource is licensed under CC0 1.0 Universal (Public Domain).