The bilateral Right Cerebrum.Sub-lobar.Lentiform Nucleus.Gray Matter corresponds to the gray matter of the lentiform nucleus in the right cerebral hemisphere, encompassing the putamen and globus pallidus, which form a major component of the basal ganglia deep within the sub-lobar region. This structure is critically involved in motor control, including the regulation of movement initiation, execution, and inhibition, as well as in procedural learning, habit formation, and certain aspects of cognition and emotion via its extensive connections with the cortex, thalamus, and other basal ganglia nuclei. Dysfunction of the lentiform nucleus is implicated in movement disorders such as Parkinson’s disease, Huntington’s disease, and dystonia, as well as in some neuropsychiatric conditions. There is no direct Wikipedia article for “Right Cerebrum.Sub-lobar.Lentiform Nucleus.Gray Matter”; a closely related entry describing the broader structure is Lentiform nucleus.
The bilateral right lentiform nucleus (putamen and globus pallidus within the sub-lobar gray matter of the cerebrum) has been implicated in multiple genetic and GWAS-based findings, largely through imaging genetics and disorder-risk studies rather than Talairach-specific work. Variants in genes affecting dopaminergic signaling (e.g., DRD2, COMT, DAT1/SLC6A3) and synaptic plasticity (e.g., BDNF) have repeatedly been associated with striatal and lentiform volume, activity, and receptor binding, often in the context of reward processing, habit formation, and motor control. Large imaging GWAS consortia (such as ENIGMA and UK Biobank–based analyses) have reported common SNPs associated with putamen and pallidum volume, highlighting loci including KNTC1, DCC, and others near genes involved in neurodevelopment, axonal guidance, and synaptic organization. Clinically, schizophrenia, bipolar disorder, obsessive–compulsive disorder, Tourette syndrome, and attention-deficit/hyperactivity disorder show genetically mediated alterations in lentiform nucleus structure and connectivity, with polygenic risk scores for these conditions correlating with striatal morphology and function. In movement disorders such as Parkinson’s and dystonia, risk variants in genes like LRRK2, SNCA, and TOR1A influence basal ganglia circuitry, including the lentiform nucleus, while addictions and substance use traits show GWAS-identified genetic overlap with striatal measures related to reward responsivity. Together, these findings indicate that common and rare genetic variation affecting neurodevelopment, dopamine and glutamate pathways, and synaptic regulation contribute to individual differences and disease-related changes in the right lentiform nucleus gray matter.
Overview generated by GPT-4o (2026).
Region ID: 640
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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