The Bilateral Control_B region in the Yeo-17 functional atlas is part of the frontoparietal control network, a set of association cortices implicated in cognitive control, flexible task switching, and the integration of sensory information with goal-directed behavior. This network typically involves regions of the lateral prefrontal cortex and posterior parietal cortex in both hemispheres, supporting functions such as working memory, decision-making, and top-down attentional modulation. Activity in Control_B subregions often correlates with the maintenance and adjustment of task rules and the coordination of distributed neural systems during complex, multi-step behaviors. There is no direct Wikipedia article for “Bilateral Control_B”; a related structure is the Frontoparietal network.
Current literature does not identify a distinct “Bilateral Control_B” region from the Yeo-17 functional atlas as a specific target of genetic association in the way that individual gyri or Brodmann areas sometimes are; instead, genetic findings typically reference the broader frontoparietal/control network within which this parcel resides. Large-scale imaging–genetics studies (e.g., UK Biobank analyses) show that functional connectivity and structural features of frontoparietal control regions are moderately heritable and genetically correlated with general cognitive ability, educational attainment, and executive-function performance, with polygenic scores for these traits predicting variation in network connectivity and activation. GWAS of resting-state network connectivity have identified common variants—often in or near genes expressed in cortex and involved in synaptic signaling and neurodevelopment—that influence connectivity strength and topology of control and default-mode networks as a whole, but parcel-level associations typically do not reach genome-wide significance or are not reported for “Control_B” specifically. Indirect evidence links genetic liability for psychiatric and neurodevelopmental disorders—particularly schizophrenia, major depression, ADHD, and autism spectrum conditions—to altered connectivity or activation in the frontoparietal control system, including bilateral dorsal lateral prefrontal and parietal regions that substantially overlap Yeo-17 control parcels. However, these findings are generally interpreted at the level of distributed networks or frontal/parietal lobes, rather than providing unique, well-replicated GWAS hits or single-gene associations that can be attributed specifically and exclusively to the Bilateral Control_B parcel.
Overview generated by GPT-4o (2026).
Region ID: 11
Hemisphere: Bilateral
Atlas: Yeo-17
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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