The Bilateral Salience_VenAttn_A region in the Yeo-17 atlas corresponds to a functional network node within the Salience/Ventral Attention system, which is implicated in detecting behaviorally relevant internal and external stimuli and in orchestrating rapid shifts of attention. This network typically encompasses portions of the anterior insula, dorsal anterior cingulate cortex, inferior frontal gyrus, and adjacent frontal–parietal opercular areas, bilaterally. Functionally, it supports dynamic switching between the default mode and executive control networks, integrating sensory, emotional, and interoceptive information to guide goal-directed behavior and autonomic responses. Activity in this system has been associated with salience processing, stimulus-driven (bottom‑up) attention, and aspects of cognitive control and affective regulation, and is frequently examined in the context of neuropsychiatric conditions involving altered attention, emotion, and network connectivity. There is no direct Wikipedia article for this Yeo-17 parcel; a closely related structure is the Salience network.
Research specifically targeting the Bilateral Salience_VenAttn_A parcel of the Yeo-17 atlas is limited, but genetic findings related to the broader salience and ventral attention networks implicate several key pathways and disorders. GWAS and imaging-genetics studies show that structural and functional variation in core salience/ventral attention regions (often including anterior insula and dorsal anterior cingulate/fronto-opercular cortex) is moderately heritable and associated with polygenic risk for psychiatric conditions such as schizophrenia, major depressive disorder, bipolar disorder, and ADHD, as well as autism spectrum disorder and Alzheimer’s disease. Variants in genes involved in synaptic function, glutamatergic and GABAergic signaling, calcium and voltage-gated ion channels, and neurodevelopment (e.g., GRIN2A/B, CACNA1C, CNTNAP2, and complement pathway genes) have been linked to alterations in connectivity and activation within these networks. Large-scale consortia (e.g., ENIGMA, UK Biobank) report that common variants influencing cortical thickness, surface area, and functional connectivity in salience/ventral attention regions overlap with genetic architectures for cognitive performance, risk-taking, neuroticism, and mood-related traits, suggesting that the Bilateral Salience_VenAttn_A region participates in a genetically influenced network underpinning salience detection, cognitive control, and vulnerability to a range of neuropsychiatric and cognitive phenotypes, even though parcel-specific associations for this exact Yeo-17 region are not yet well resolved.
Overview generated by GPT-4o (2026).
Region ID: 8
Hemisphere: Bilateral
Atlas: Yeo-17
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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